Methemoglobinemia associated with loxoscelism

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Reported adverse event cases of methemoglobinemia associated with benzocaine products.

BACKGROUND Methemoglobinemia (MHb) is characterized by abnormal levels of oxidized hemoglobin that cannot bind and transport oxygen. When induced by benzocaine anesthetic spray and other chemicals, it can result in cyanosis and life-threatening complications. METHODS From 818 439 adverse event reports received by the US Food and Drug Administration from November 1997 through March 2002, we ex...

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Congenital Methemoglobinemia

Congenital methemoglobinemia is a rare cause of cyanosis. We report a case of a girl, 17 years old with peripheral cyanosis and normal cardio-pulmonary system. She was diagnosed as a case of methemoglobinemia based on findings of polycythemia and HbM band on hemoglobin electrophoresis. We emphasize the importance of this rare entity in the differential diagnosis of cyanosis.

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About methemoglobinemia.

I would like to add to this well written article that we have also reported acquired methemoglobinemia cases with administration of cytanest in puerperal women with g6PD deficiency and infants in whom erythrocyte cytochrome 65 reductase was assoyed [1-4], which is the main enzyme for methemoglobin reductase in erythrocytes as mentioned by the authors. In addition, hereditary methemoglobinemias ...

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A Case of Loxoscelism in Southern France

An 80-year-old man living in Fréjus in southern France had a cellulitis on the right arm (Figure 1). The patient had no fever, chills, systemic symptoms, or other clinical signs. He felt a slight pain in his arm during the night and while folding his arm, he crushed a spider. The spider’s body was immediately recovered and then identified by an entomologist (Figure 2). This typical skin lesion ...

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A 9-year-old child with methemoglobinemia.

A 9-year-old boy presented to the Dermatology Department for the follow-up of a bullous pemphigoid. This diagnosis had recently been established based on his clinical picture and immunologic test results, and he had begun treatment. He was found to have methemoglobinemia as determined from an arterial blood sample (Table 1). This analysis was done using a Radiometer ABL 735 analyzer in our Depa...

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ژورنال

عنوان ژورنال: Revista do Instituto de Medicina Tropical de São Paulo

سال: 1990

ISSN: 0036-4665

DOI: 10.1590/s0036-46651990000100001